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Journal of Bacteriology, October 2000, p. 5592-5595, Vol. 182, No. 19
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Revised Translation Start Site for secM Defines an Atypical Signal Peptide That Regulates Escherichia coli secA Expression

Shameema Sarker,1 Kenneth E. Rudd,2 and Donald Oliver1,*

Department of Molecular Biology and Biochemistry, Wesleyan University, Middletown, Connecticut 06459,1 and Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 331012

Received 30 November 1999/Accepted 6 July 2000

The secretion-responsive regulation of Escherichia coli secA occurs by coupling its translation to the translation and secretion of an upstream regulator, secM (formerly geneX). We revise the translational start site for secM, defining a new signal peptide sequence with an extended amino-terminal region. Mutational studies indicate that certain atypical amino acyl residues within this extended region are critical for proper secA regulation.

* Corresponding author. Mailing address: Department of Molecular Biology and Biochemistry, Wesleyan University, Middletown, CT 06459. Phone: (860) 685-3556. Fax: (860) 685-2141. E-mail: doliver{at}wesleyan.edu.

Journal of Bacteriology, October 2000, p. 5592-5595, Vol. 182, No. 19
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Nakatogawa, H., Murakami, A., Mori, H., Ito, K. (2005). SecM facilitates translocase function of SecA by localizing its biosynthesis. Genes Dev. 19: 436-444 [Abstract] [Full Text]  
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  • Butkus, M. E., Prundeanu, L. B., Oliver, D. B. (2003). Translocon """Pulling""" of Nascent SecM Controls the Duration of Its Translational Pause and Secretion-Responsive secA Regulation. J. Bacteriol. 185: 6719-6722 [Abstract] [Full Text]  
  • Sijbrandi, R., Urbanus, M. L., ten Hagen-Jongman, C. M., Bernstein, H. D., Oudega, B., Otto, B. R., Luirink, J. (2003). Signal Recognition Particle (SRP)-mediated Targeting and Sec-dependent Translocation of an Extracellular Escherichia coli Protein. J. Biol. Chem. 278: 4654-4659 [Abstract] [Full Text]  
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  • Tian, H., Beckwith, J. (2002). Genetic Screen Yields Mutations in Genes Encoding All Known Components of the Escherichia coli Signal Recognition Particle Pathway. J. Bacteriol. 184: 111-118 [Abstract] [Full Text]  


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