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FIG. 3. Nitrogen source regulation of nif gene transcription in A. vinelandii. Under conditions of fixed-nitrogen limitation (-N), GlnK is mainly uridylylated and not competent to interact with NifL. Under these conditions, binding of 2-oxoglutarate to the GAF domain of Av NifA relieves inhibition by Av NifL, freeing NifA to activate transcription. Under conditions of fixed-nitrogen sufficiency (+N), GlnD deuridylylates GlnK, which interacts with NifL, promoting formation of the NifL-NifA complex.
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