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FIG. 1. Catabolic pathway for degradation of biphenyl and organization of the bph gene cluster in P. pseudoalcaligenes KF707. Compounds: I, biphenyl; II, 2,3-dihydroxy-4-phenylhexa-4,6-diene (dihydrodiol compound); III, 2,3-dihydroxybiphenyl; IV, HOPD (biphenyl meta-cleavage compound); V, benzoic acid; VI, 2-hydroxypenta-2,4-dienoic acid; VII, 4-hydroxy-2-oxovaleric acid; VIII, pyruvic acid; IX, acetaldehyde; X, acetyl-coenzyme A. The BphR1 protein, belonging to the GntR family, is a transcriptional regulator involved in the expression of bphR1 and bphX0X1X2X3D. The function of orf3 remains unclear (83, 84). ISP, iron-sulfur protein.
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