JB Accepts, published online ahead of print on 23 October 2009

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J. Bacteriol. doi:10.1128/JB.01330-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Complete Genome Sequence of Anaplasma marginale ss. centrale

David R. Herndon, Guy H. Palmer, Varda Shkap, Donald P. Knowles Jr., and Kelly A. Brayton^*

Animal Diseases Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Pullman, Washington 99164 USA; Programs in Vector-borne Diseases and Genomics, Department of Veterinary Microbiology and Pathology and School for Global Animal Health, Washington State University, Pullman, Washington 99164 USA; Division of Parasitology, Kimron Veterinary Institute, Bet Dagan, 50250, Israel

^* To whom correspondence should be addressed. Email: kbrayton{at}vetmed.wsu.edu.

Anaplasma marginale ss. centrale is a naturally attenuated subtype that has been used as a vaccine for a century. We sequenced this genome and compared it to virulent senso stricto A. marginale strains. The comparison markedly narrows the number of outer membrane protein candidates for development of a safer inactivated vaccine and provides insight into the diversity within senso lato A. marginale.