JB Accepts, published online ahead of print on 30 October 2009

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J. Bacteriol. doi:10.1128/JB.01188-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Endogenous phenazine "antibiotics" promote anaerobic survival of Pseudomonas aeruginosa via extracellular electron transfer

Yun Wang, Suzanne E. Kern, and Dianne K. Newman

Antibiotics are increasingly recognized as having other, important physiological functions for the cells that produce them. An example of this is the effect phenazines have on signaling and community development for Pseudomonas aeruginosa (e.g. (8)). Here we show that phenazine-facilitated electron transfer to poised-potential electrodes promotes anaerobic survival but not growth of Pseudomonas aeruginosa PA14 under conditions of oxidant limitation. Other electron shuttles that are reduced but not made by PA14 do not facilitate survival, suggesting the survival effect is specific to endogenous phenazines.