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Journal of Bacteriology, November 2009, p. 7123-7128, Vol. 191, No. 22
0021-9193/09/$08.00+0     doi:10.1128/JB.00731-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

A 5' Leader Sequence Regulates Expression of Methanosarcinal CO Dehydrogenase/Acetyl Coenzyme A Synthase{triangledown} ,{dagger}

Kimberly L. Anderson, Ethel E. Apolinario, Sheridan R. MacAuley, and Kevin R. Sowers*

Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Columbus Center, Suite 236, Baltimore, Maryland 21202

Received 4 June 2009/ Accepted 11 September 2009

In vivo expression of CO dehydrogenase/acetyl coenzyme A synthase in Methanosarcina spp. is coordinately regulated in response to substrate by at least two mechanisms: differential transcription initiation and early elongation termination near the 3' end of a 371-bp leader sequence. This is the first report of regulation of transcription elongation in the Archaea.

* Corresponding author. Mailing address: Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 E. Pratt St., Baltimore, MD 21202. Phone: (410) 234-8878. Fax: (410) 234-8896. E-mail: sowers{at}comb.umbi.umd.edu

{triangledown} Published ahead of print on 18 September 2009.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, November 2009, p. 7123-7128, Vol. 191, No. 22
0021-9193/09/$08.00+0     doi:10.1128/JB.00731-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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