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Journal of Bacteriology, May 2008, p. 3779-3785, Vol. 190, No. 10
0021-9193/08/$08.00+0     doi:10.1128/JB.01861-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Quantitative Analysis of Three Hydrogenotrophic Microbial Groups, Methanogenic Archaea, Sulfate-Reducing Bacteria, and Acetogenic Bacteria, within Plaque Biofilms Associated with Human Periodontal Disease{triangledown}

M. E. Vianna,1 S. Holtgraewe,2 I. Seyfarth,1 G. Conrads,1 and H. P. Horz1*

Division of Oral Microbiology and Immunology, Department of Operative and Preventive Dentistry and Periodontology, and Department of Medical Microbiology, RWTH Aachen University Hospital, Aachen, Germany,1 Department of Operative and Preventive Dentistry and Periodontology, RWTH Aachen University Hospital, Aachen, Germany2

Received 27 November 2007/ Accepted 1 March 2008

Human subgingival plaque biofilms are highly complex microbial ecosystems that may depend on H2-metabolizing processes. Here we investigated the ubiquity and proportions of methanogenic archaea, sulfate reducers, and acetogens in plaque samples from 102 periodontitis patients. In contrast to the case for 65 healthy control subjects, hydrogenotrophic groups were almost consistently detected in periodontal pockets, with the proportions of methanogens and sulfate reducers being significantly elevated in severe cases. In addition, antagonistic interactions among the three microbial groups indicated that they may function as alternative syntrophic partners of secondary fermenting periodontal pathogens.

* Corresponding author. Mailing address: Division of Oral Microbiology and Immunology, RWTH Aachen University Hospital, Pauwelsstrasse 30, D-52057 Aachen, Germany. Phone: 49-241-8088448. Fax: 49-241-8082483. E-mail: jhorz{at}ukaachen.de

{triangledown} Published ahead of print on 7 March 2008.

Journal of Bacteriology, May 2008, p. 3779-3785, Vol. 190, No. 10
0021-9193/08/$08.00+0     doi:10.1128/JB.01861-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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