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Journal of Bacteriology, November 2005, p. 7866-7869, Vol. 187, No. 22
0021-9193/05/$08.00+0     doi:10.1128/JB.187.22.7866-7869.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Tryptophan Catabolism: Identification and Characterization of a New Degradative Pathway

Keri L. Colabroy^1* and Tadhg P. Begley²

Department of Chemistry, Muhlenberg College, 2400 Chew Street, Allentown, Pennsylvania 18104,¹ Department of Chemistry and Chemical Biology, 120 Baker Laboratory, Cornell University, Ithaca, New York 14853²

Received 4 June 2005/ Accepted 24 August 2005

A new tryptophan catabolic pathway is characterized from Burkholderia cepacia J2315. In this pathway, tryptophan is converted to 2-amino-3-carboxymuconate semialdehyde, which is enzymatically degraded to pyruvate and acetate via the intermediates 2-aminomuconate and 4-oxalocrotonate. This pathway differs from the proposed mammalian pathway which converts 2-aminomuconate to 2-ketoadipate and, ultimately, glutaryl-coenzyme A.

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* Corresponding author. Mailing address: Department of Chemistry, Muhlenberg College, 2400 Chew St., Allentown, PA 18104. Phone: (484) 664-3665. Fax: (484) 664-3546. E-mail: colabroy{at}muhlenberg.edu.

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Journal of Bacteriology, November 2005, p. 7866-7869, Vol. 187, No. 22
0021-9193/05/$08.00+0     doi:10.1128/JB.187.22.7866-7869.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

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